Debonaire + Cipher (especially Beguiler) is a good combo. You can almost guarantee a crit with Soul Ignition or Disintegrate on a charmed target. Best thing is that charmed targets don't flip back if you hit them with Disintegrate (or Soul Ignition).
And should you run out of focus for whatever reason (like only few enemies left to hit with Deceptions): a Debonaire can still dish out high dmg Sneak Attacks like every other Rogue.
Cipher combos I like:
Furyshaper/Beguiler (the Horror): White Witch Make, Willbreaker Morning Star (modal always on), Fear Ward, Phantom Foes, Secret Horrors, Spirit Frenzy, Brute Force, Blood Thirst (among others). Lowers Fortitude and Will on single targets and in an AoE, builds up focus real fast due to Beguiler mechanics, disables lots of foes completely with the Fear Ward (Will debuff of Furyshaper gets balances out by Cipher's high Will). Morning Star and other debuffs make landing stuff like Disintegrate really easy - and once the Blood Thirst gets rolling... Also works well with Ascendant - especially Blood Thirst during Ascension. I just like Beguiler better - also because of thematical reasons. Main focus is debuffing Focus and Will.
Forbidden Fist/Beguiler (the Dissolver): Forbidden Fist ability doesn't generate focus, so you need another source, hence Beguiler. With Community Patch (which "fixes" the ability so it generates focus) Forbidden Fist/Ascendant may be even better. Anyway: Forbidden Fist applies Enfeebled which not only lowers Fortitude by 10 (combine with Stunning Surge for another debuff of 10) but also prolongs hostile effects by 50%. Disintegrate is such a hostile effect. If you also crit your Disintegration will have a +100% duration. Ouch. You can make crits with Disintegrate more likely with a Morning Star + modal. But I like fists better in this case. Works with all other afflcitions, too. So if you hit a guy and then cast Whispers of Treason he's charmed for +50% time. Combine with Lingering Echoes and high INT (Turning Wheel) for absolutely absurd durations. Dominated Enemies will fight for you forever (kind of). Also dominating enemies doesn't cost much because Beguiler. I play it with highest RES possible, Tuotilo's Palm and add food and items that shorten hostile durations.
Stalker/Soulblade: Takedown Combo + Soul Annihilation or Soul Ignition and Disintegrate. Unlike with direct damage, Disintegrate and Soul Ignition apply "pure" DoTs that don't cancel Takedown Combo. Still Takedown Combo applies its dmg boost to all the ticks of the DoTs, meaning those spells get +100% damage. Which is very good. Disintegrate and also Takedown Combo do target fortitude, so it's good to debuff that first (by party or yourself). I used a Morning Star myself again. Soul Annihilation + Takedown Combo is Overkill in most cases but really packs a punch against the big ones. This should also work very well with a Rapier since you can use it single handed + modal in the early game wich makes not missing with Soul Annihilation really easy. Later maybe add a Dagger or Stiletto for faster focus gain. You can get the Spider's Fang Rapier that is very good with Ciphers. I hear it's also very good on Monk/Ciohers. Hunter's Claw gives you plenty of ACC and more deflection, it's great.
Helwalker/Ascendant: self explanatory it seems. Huge AoE, big damage, long Ascension, increased PEN through Thunderous Blows etc. Works brilliantly with mortars as well.
Soulblade/Trickster: Offensive Parry from Whispers of the Endless Paths, Riposte Mirrored Images + Borrowed Instincts, max RES, pile up deflection via items and buffs. Blind enemies for reduced Accuracy and to unlock Deathblows. Offensive Parry and Riposte will fill up your focus quickly while you can strike normally, building up focus really fast. Then dump all the focus into a cone with WotEP+Soul Annihilation - Sneak Attack, Deathblows all apply. Rinse and repeat. You can spam Soul Annihilation all the time when fighting lots of weaker enemies who miss you in melee. Against single foes you can always switch to something with better single target damage - like Voidwheel or so. That class combo is also nice with Sun and Moon + shield instead of WotEP. Less parrying, bit the dual heads work very well with Soul Annihilation: first of all you get two chances to hit - and if both hit the first one applies the raw damage while the second already refills focus.
Recently I have come to like the Psion more. A Troubadour/Psion for example can cast invocations/cipher spells nonstop. While phrase counter is refilling you can cast from focus and vice versa. Also Wizard/Psion ist pretty hilarious at some point: you make yourself invisible with Arkemyr's Brilliant Departure and prolong it with Wall of Draining, then cast Cipher-CC powers from invisibility which don't break it (as long as no damage). A Priest/Psion can even cast Withdraw on himself; he can then emerge with full focus and health from the Withdraw. Not always useful, but a nice little synergy. Tactician/Psion could be nice because Phantom Foes will flank all enemies and the Psion's interrupt ability will restore Discipline if used wisely. Not so good in melee though since that will stop the focus generation. Go ranged with Penetrating Strikes I guess. Haven tried that one out yet though.