Most are pretty straightforward.
Fighter/Rogue distraction tank with Cadhu Scalth (+modal), Kapana Taga, Reckless Brigandine, Hold the Line, Helm of the Champion, Entonia Signet, +Protection and +Deflection gear, Persistent Distraction, Armored Grace, Adept Evasion, Riposte, Mob Stance, Refreshing Defense, Deathblows, Unbending (and so on). Basically like an Unbroken/Trickster but without the goodies of both classes. Still works very well. Goal is to have a sticky tank with 5 engagement slots without using Defender Stance. The items help a lot in that regard. Also works with Defender Stance if you want other gear and more defensive capabilities. Anyway you only need enough staying power to bind lots of enemies to you at the start of combat. You distract all of them automatically (very nice passive auto-debuff with no "saving throw"). You will still deliver decent melee dmg but at the same time be nearly impervious to ranged and AoE dmg (shield modal + Adept Evasion). Because of that you can get hit by your teammates' AoE spells (e.g. your Wizard's) and don't care much. Usually your bound enemies do care though and die.
SC Watershaper with Deltro's Cage + Lord Darryn's Voulge as "stat stick". Or same with him as Watershaper/Stormspeaker.
Herald tank. High defenses and passive healing. Fat armor, Lethandria's Devotion, Sasha's Singing Scimitar (Shopcking Prelude + Refreshing Finale: use empowered White Worms and later empwered Eld Nary), Blackened Plate Armor with "Life in Death", Exalted Endurance + Ancient Memory and so on. Keep near your allies.
Scout with focus on arquebus. All the stuff that increases arquebus dps: Gunner, Marksman, Driving Flight, Stalker's Link, Marked for the Hunt, Deathblows, Accurate Wounding Shot, Arterial Strike, Blinding Strike, maybe Pierce the Bell against the really high AR foes (it has +5 PEN). And so on. Maybe not Toxic Strike since her INT is pretty low. Use the Red Hand or Dragon's Dowry. Dragon's Dowry is one of the best weapon for backstabbing: sneak up to a target, use Arterial Strike to "backstab" and immediately retreat with either Escape or Evasive Roll (usually Evasive Roll is better since you need more Guile than Bond in an encounter). If you use Escape and enchanted her armor with "Return Fire" and also pick Superior Camouflage it's not uncommon to trigger Return Fire's crit conversion often. If you don't want to backstab then just stick to the Red Hand and fire away.
SC Wizard - nothing special. Grimoire of Vaporous Wizardry, Rekvu's Fractured Casque. Injure yourself with Necrotic Lance in between fights so you always carry an Acute Rash injury (it's a very minor debuff but you gain immunity to interrupts and +1 spall casts per spell tier). Either go for Chromprismatic Staff as stat stick (Power Level bonuses) or Blightheart (+10% corrosive lash for spells is great) or Griffin's Blade + a small shield for more staying power and a bit increased spell dmg. Or use Magran's Favor + Sun & Moon for your fire spells.
SC Wizard "The Terror": use Effigy's Husk + Whitewhitch Mask + Eye of Wael (=+3 PL to illusions) and aim for Illusion spells like Miasma + Curse of Blackend Sight, Repulsive Visage and Enervating Terror, Gaze of the Adragan, Wall of Many Colors, Kalakoth's Freezing Rake. You can use a club + modal to lower Will by 25 on a single target if you wish. Best in this case might be Shattered Vengeance with "Coordinated Escape". Very strong debuffer (lower Will to the ground with Misama and then terrify the heck out of everybody) but also later a strong damage dealer with Freezing Rake. Use Concelhaut's Draining Touch + Essential Phantom for this trick: the Draining TOuch will not go away on a Phantom after a succesful hit, so it can keep hitting the enemy with it, It does very high corrode damge. Especially since it targets will and not deflection. You are a strong strong will debuffer: see the synergy? The Phantom will hit enemies like a truck because it frequently crits with Draining Touch. It will heal itself in the process (draining) and apply weakened to the target. If it drops below 50% health it will also cast Repulsive Visage because of the mask. If it dies it will trigger the Husk's raw AoE attack on death. If you use Shroud of the Phantasm you can do all that times 6 (six Phantoms) - but of course only 1/rest. If you use Arkemy'r Grimoire there's an Illusion spell names "Arkemyr's Brilliant Departure" which makes you invisible and doesn't break if you only cast CC on enemies (no damage though). That means that you can cast for example a Miasma on a crowd without becoming visible. It's like CC god mode a bit. Also Wall spells (Wall of Many Colors but also Wall of Flames) will not end the invisibility because they are hazards (their own game character entity) which will not be connected to you dealing damage.
SC Priest- Very straightforward - just works. Use her lantern - it's great for that. User her as main support/secondary healer and kind of offtank.
SC Monk. As melee Monk use her fists mostly and aim for Whispers of the Wind + Resonant Touch and make her the main damage dealer in order to get something out of her subclass.
As mid-ranged SC Monk: use Serafen's two Hand Mortars and go gunmonk. This is very strong with Stunning Surge, Flagellanth's Path and Whispers of the Wind/Resonant Touch. Use Lightning Strikes, Duality of mortal Presence (INT) - no need to pick Turning Wheel since it's melee only. Pick everything that gives you ACC, PEN and INT (AoE size): Enduring Dance, Thunderous Blows, Razor's Edge, Ring of Overseeing, Ring of the Marksman, Aloth's Armor, Heaven's Cacophony and so on. Start fights with Enduring Dance and then fire away with Stunning Surge. Use wounds for Thunderous Blows in between, later for Whispers of the Wind and Resonant Touch as well. Stunning Surge will ost nothing if it crits only once in the AoE and you will even get back Mortification from her class passive if you kill (which happens a lot if she's the main AoE damage dealer). She works great with a single-target-focused Maia Rua: Maia picks off the dangerous single targets, Xoti wrecks the mobs. This woirks very well with a stiyk tank Edér and Aloth using Pull of Eora to cramp as many mobs a possible into a tight space. Also Aloth can use Dazzling Lights to lure enemies from stealth into a tight spot where Edér then egages and Aloth casts Pull of Eora. If you use Pull of Eora much gie Edér an item that makes him immune to push/pull effects (like the Horns of the Aurochs or the Upright Captain' Belt - very good in this case).
In all monk cases go for Precognition as amulet and Stalking Cloak for the back. Whispers of the Wind makes you invisible so you will stun every enemiy you hit with it.
Serafen (I like him if that isn't obvious):
Witch with Willbreaker and White Witch Mask, use Blooded - works very well with the Mask. Use Spirit Frenzy/Tornado to apply Staggered (-10 Fortitude) and Secret Horrors to apply SIckened (another -10 Fortitude). Cast Borrowed Instincts a lot (+20 ACC besides other stuff) and hit enemies with the modal "Body Blows" on (-25 Fortitude) - then using Soul Ignition/Disintegrate and other fortitude based stuff on them. Your accuracy will virtually be +65(!). Use Brute Force to target fortitude instead of deflection if it's lower (often is with the Morning Star + Sprit Frenzy + Secret Horrors). The Morning Star also lowers Will (-3 per hit) which is great for most other cipher powers that don't target fortitude. Also use Psychovampiric Shield to lower enemies Will by -20 and Deflection by 10. Use Whisper of Treason and/or Puppet Master, too. Although you are a melee guy you should use these because they are very strong. Don't hit your charmed enemies - else they flip back. Let them fight for you instead. Skill your Will into the sky (Iron Will +15 & Bull's Will +10) and use the highest shock AR gear you can find (so.. NOT plate armor). When casting, don't be too near to your allies in case you miscast (can wipe your friends). Use Deltro's Cage Helmet to profit from the miscast (if you survive).
Witch with Lord Darryn's Voulge, Deltro's Cage - mostly applying Static Charges with Carnage and using Soul Shock on your tank.
SC Barb, aiming for Driving Roar with Blood Thirst, Bloodlust, Spirit Frenzy, Acina's Tricorn, Lance of the Midwood Stag (Lord of the Forest). Let a fellow druid cast Woodskin or Form of the Delemgan on you right at the start of battle. Or count on the weapon's enchant,ment to give you Woodskin at some point. In this case it can be good to also wear Nature's Embrace. Gain +2 PL and attack from second row with Spirit Frenzy + Carnage and use the yell/roar to deliver dmg and apply Shaken, Daze and Staggered as AoE CC until you get Driving Roar. At that point just be your party's best ranged damage dealer with incredible dmg output for just 1 Rage per cast. Also pick Improved Critical etc. Against crush-immune or resistant enemies either use your Lance or pick Instrument of Boundless Rage. Use two Necklaces of Fireballs: one in the stach and one on your neck. Before getting Driving Roar cast up tp 8 Fireballs per encounter (trigger Staggered with Spirit Frenzy, Blooded also works and so do Frenzy and Bloodlust/Blood Thirst for casting speed) after encounter stack the empty necklace with the full one in the stash - tada: both have 8 charges again.
If you like fire attacks a lot you can also go Magran's Favor (+ Bleeding Cuts) + Sun & Moon + Instruments of Boundless Rage + Necklace of Fireballs + Spirit Tornado + Dragon Leap + Barbaric Shout + Barbaric Retaliation + Blunting Belt + Patinated Plate (Bronze Juggernaut + Constant Reboud) + Death's Maw + Stalwart Defiance + Thick Skinned + Blooded + One Stands Alone + Heart of Fury + Barbaric Smash + Blood Surge + Blood Thirst + Bloodlust (hope that all fits into one char Can't remember the exact portfolio). Maybe also use Three Trolls Stiched or Nemnok's Cloak. Ragged Cloak for more retaliation damage. Jump into the midst of the enemy and let them hit you. With dazing and such high AR they won't do much damage but crit you a lot, triggering Barbaric Retaliation with Bleeding Cuts and self heal from Sun & Moon. If you're too low on hralth use Stalwart Defiance. All the while cast Fireballs from the Necklace or use Instrument of Boundless Rage or simply Barbaric Smash. All your fire based attacks will have +4 Power Level during daytime.
Suicide Bomb - SC Barb: use Effigy's Husk, Effort, Shroud of the Phantasm in hard fights, else Mantle of the Seven Bolts, Vengeful Defeat, Heart of Fury, Pather's Leap, Blooded, Accurate Carnage, Blood Storm and so on. Jump into enemies and start hacking away. You want to be very fast but not too fragile. Should you go down: Deal tremendous AoE damage from Effort (Full AoE Attack), Husk (Raw AoE attack), Vengeful Defeat (Full AoE attack) and Mantle (Shock AoE attack) to everything around you. Get revived by a Paladin, Priest, Druid or Chanter and try again. Very good on itself but not if you don't like resting. In tight encounters use the Shroud to summon 6 copies of you which have low health and do the same on death as you: EXPLODE! . Nothing except fat bosses might survive this if your timing/position is good... If you want you can copy the Ring of Reset from the Deck of Many Things. You can do that without the console if you export a custom character with the ring (use a lvl-1-adventurerer with only the ring - to avoid hich recruitment costs). Hire him then in the other game in a tavern and take the Ring. Now you have two. They can form a stack in the stash. If one is emoty stack it with the other one and it will be recharged. This way you can go down 3 times in an encounter (trigger AoW dmg) and get back up right again without taking an injury. It's cheesy - but if you like that build idea but hate resting this might be your thing. It's a lot of fun. By the way: Ring of Reset doesn't work on Phantoms... (see Aloth).
Well... some might not be that straightforward now that I read all this again...