That's what I like about V Rising, it's a really good ARPG combat system on top of a really good survival game. It's the one survival game I keep coming back to, I've had the most fun with it out of all survival games that have come out in the last 3-4 years, beats Valheim for sure.
OK, I have never played any DS, but I have 40 hours in Sekiro on PC, and 2 hours in Bloodborne on PS4. Played Elden Ring when it came out for about 100 hours on mouse + kb, reinstalled this week to try with a controller, played for 2 hours, beat 2 bosses, slowly getting back into it.
Anyway, I just couldn't play it with the default M+KB scheme, I kept pressing the wrong buttons due to thousands of hours playing various ARPGs. After rebinding all of the keys it became playable, and I actually found one thing that beats controllers any time: camera control - you don't even need to lock onto enemies it's so precise, and not locking onto some enemies actually gives you an advantage.
Now playing with a controller camera movement is the one thing I am having trouble with, really hard to orient myself without locking onto enemies, and combat becomes messy against groups of enemies. People do get used to it, so my advice would be to stick to what you're more comfortable with and building up some muscle memory.
One tip I'll give you that really saved me regardless of what input device you'd want to use: there are many UI interactions that aren't explained in the game at all but they make combat much more enjoyable, and I'd suggest you looked them up. For example, the item quickbar in the left bottom corner has two sets you can switch between by holding down the "Interact" button. So you effectively have extra 4 slots for consumables that are easily accessible without having to scroll through them. I have only my healing flask in the default slot, so I cannot skip through it accidentally, and the consumable button always heals no matter what. The mana flask, the mount, the summoning bell etc. - all are on the second layer of slots, all having their dedicated buttons, this setup greatly helped me with my combat flow.