NV did it best. Kill a certain NPC and certain quests immediately failed or were resolved immediately.
I wish the same were true with Ulfric Stormcloak and various other twits in Skyrim.
I couldn't stand Anders in Awakenings, but I didn't dislike him in DA2. My hatred was reserved for Bonnie Prince Charlie. So satisfying to see his outrage after the Chantry literally blew up in his face.
Tried Bully, turned out to be unplayable due to probably worst controls I've ever encountered in a game since Prince of Persia 3D. Uninstalled after an hour and wish I could delete it from my Steam library.
Started Saint's Row 2 instead. Good stuff.