Absolutely. I prefer playing a female PC, just because I can relate to the character more (same reason why my D&D, Shadowrun and Rifts characters were always female, when I played back in high school... you know, before the war of 1812.).
However, while I prefer playing a female PC, I still have played male PCs in the past in other games. So being limited to a male PC doesn't stop me from purchasing or playing a game... having the option of a female PC does however make the game more enjoyable.