I'd like an RPG that uses most of the neat design choices that Jefferson used. Such as being able to talk to people who are hostile, the epithets, etc. Several factions that give either roleplaying, or material benefits, or both. Reactive world, where your reputation and actions actually mean something. I'd also like the following features:
Fantasy RPG:
A growing town, one you can contribute to that will grow throughout the game with new immigrants and such, and you can have buildings built there that you would own and be able to customize, giving you something other than magic items to spend all your money on.
Rare magic. If you're a wizard, I want people to be awed, I want the magic items you find to be priceless artifacts, etc. The damage you deal should be based on your skill, not how beefed up your weapon is.
Sci-Fi RPG:
Tech level: more of a Babylon 5 tech level, with jumpgates rather than hyperdrive.
Customizable transportation. Be able to customize the look, style, options, etc. of your stronghold vehicle (space ship kinda thing)
option to mechanically augment your body, which shows on your avatar.
I guess the growing town thing could also apply here, only it would be more like a space station port kind of thing.