The problem is, vampires have always been really lame since they've always lacked the awesome powers they have in the lore. Now Bethesda gives us Bram Stoker vampires, complete with shapeshifting into bats.
Bethesda can do interesting things with the plot, though, since Molag Bal seems to be involved judging from the trailer. Molag Bal made the first vampire by raping a woman. Also, both in Morrowind expansion and Oblivion expansion a Daedric prince had been central to the plot.