Warhammer, Warhammer 40K, White Wolf, Arcanum (Troika's), Battletech, Heavy Gear, Call of Cthulhu ect.
So many materials out there. If Obsidian managed to grow balls of brass after the release of AP and Aliens, they could look back to review one of the highly hyped but dropped IP during the Black Isle days: Torn.
I don't know Heavy Gear and Arcanum wasn't really my cup of tea from it's description (I am not a steampunk fan), but the rest would make for a nice change. I am still dying of curiosity about what the project (insert state name) was that made an appearance as a forum section and then disappeared again was.