I've never had problem with the quality of the games. My contention is that the B-movie humor of Duke will easily show through as trying too hard to be funny with modern game design. They'll inherently be forced to provide more context to the adventure than in the previous games, which automatically means that facet of it will gain more prominence.
If they apply Duke Nukem's B-movie style to the entirety of the setting, it will invariably end up with brain cells dying for every member of the audience. Whereas if they set up the setting so that it's all fairly serious, but Duke comes in and provides the comic relief, they could pull it off.
All I ask is that when Duke Nukem gives off one of his atrocious one liners, someone in-game tells him to shut the hell up.