BG2, DAO, and basically all other Bio games. Yeah, my expectations aren't quite that high.
I think BIO has a good track record of fixing bugs that actually totally screw up a play-through. So I think there's a good chance Thumbs Up will get fixed, as it has done for some players.
Otherwise, I agree with you.
DA:O actually has a pretty good modding scene, with a bunch of neat fix-type mods for it. Including a fix-pack, auto-looter (love this!), skip-the-fade, and some others.
But nothing on the level of Baldurdash or Weimer's stuff, yeah.