I find games have been shying away from too much true player agency. If they allow both Camarilla and Sabbat characters, and not just the level of choices from the original Bloodlines, they would need to create twice the content really, as neither the npcs nor locations could properly overlap. An indy dev may do that and have a project that takes years to even get into Early Access. A triple A title which wants to amaze us with snazzy effects? I doubt it.
The multiple origins in Dragon Age: Origins are probably the most different content we'll ever see in a "big" RPG.
Old Republic is the one RPG that did anything like that and it is an MMO. If they had only brought that out as a series of stand alone, single player RPGs with one game per character. It could have been wonderful.