1. (Personal highest regarded choice)
- A Fallout style original RPG in scifi (not in space, though), cyberpunk or steampunk setting.
- Isometric (default) camera (but with options to zoom in and out, and camera rotation).
- Tactical turnbased combat.
- Partymember control would be nice but I wouldn't hold it against the game if it was not there.
- Properly complex and rewarding characterdevelopement and overall rulesystem.
- Multipath multisolution quests.
- Lots of dialog.
- Choices with actual consequences.
- Moral ambiguousness in the setting and stories.
- Adult themes handled in adult manner.
- Themes of political powerplay, racism, religion, violence, etc.
- More down to earth plot (no nameless random chosen one saving the world from an ancient evil).
- No minigames (in the sense of lockpicking and hacking in New Vegas and Fallout 3), but all actions being done by character according to his/her skill.
...in a nutshell.
Serious business. :D
2. Another game in the Planescape setting. This time with well done TB combat.
3. Another Vampire: The Masquerade game.