1.  (Personal highest regarded choice) 
- A Fallout style original RPG in scifi (not in space, though), cyberpunk or steampunk setting. 
- Isometric (default) camera (but with options to zoom in and out, and camera rotation). 
- Tactical turnbased combat. 
- Partymember control would be nice but I wouldn't hold it against the game if it was not there. 
- Properly complex and rewarding characterdevelopement and overall rulesystem. 
- Multipath multisolution quests. 
- Lots of dialog. 
- Choices with actual consequences. 
- Moral ambiguousness in the setting and stories. 
- Adult themes handled in adult manner. 
- Themes of political powerplay, racism, religion, violence, etc. 
- More down to earth plot (no nameless random chosen one saving the world from an ancient evil). 
- No minigames (in the sense of lockpicking and hacking in New Vegas and Fallout 3), but all actions being done by character according to his/her skill. 
...in a nutshell. 
  
Serious business. :D 
  
2. Another game in the Planescape setting. This time with well done TB combat. 
  
3. Another Vampire: The Masquerade game.