My loss is only things that i do realy miss... and believe me, i will never miss any **** like that...
Well surely you won't miss the DRM measures, but what if your most favorite game gets released (and you know you want it), but also uses some DRM?
My most favourite game of 2008 was Mass Effect, and i do not miss at all that i never played that game, i used the saved 50 EUR to purchase 5 Platinum Edition Games for PS1/2, i had so much fun, that i realy do not remember when was the last time i enjoyed my gaming time so much...