You can hotkey some of the menu stuff or something (I read how, but can't remember offhand), which apparently many don't realize at first, but don't know if that helps the situation...maybe you can hotkey to a mouse button. I'll have to wait and see tho. Hope it's something I can get used to because for my hands controllers are usually worse than a bad PC UI.
...and yeah, I think it does have mouse acceleration. .ini tricks to the rescue, perhaps.