I just finished the game for the first time and even though I'm generally positively inclined about the game, I have to say that this is probably the only RPG I ever played where the loot left me completely depressed (quite literally so). I scoured the Deadfire inch by inch, spending 180 hours trying to find some sweet loot that would bring a smile to my face - and yet most loot that I found (or tried to buy) came with HUGE negative conditions that you have to apply to yourself in order to get a small benefit.
It's like the devs went out of their way to troll me. "Oh I bet you'd want to have that +4 strength, wouldn't you? Well, you can only have it if you're carrying an injury! Oh, I bet you'd love to get that +30% damage boost to your attacks! Well, your party member has to be knocked down for you to get it!"
Seriously, whoever came up with that design should really stay as far away from loot as possible! I mean, I reached max level relatively fast (after only 30 or 40 hours). There was still over 100 hours of content out there, so I went exploring and all I found in those 100 hours were a few items that only marginally improved my character (like cape of greater deflection and Aeldys' sword). I went through all the expansions and only the Forgotten Sanctum had one interesting ring with 10% chance to throw a random affliction on critical hit and one interesting pet that gave me +5 accuracy. Not sure if these two things even improved my character that much. Whopde doo!
In PoE1 I started the game with 17 STR, 14 INT and 16 RES. By the end of PoE1 my strength was over 30, my INT was over 20 and my resolve was 25 without any buffs and any min-maxing. In PoE2, I started the game with the same character and barely managed to get my STR to 22 with only +1 to resolve, intelligence and perception. What happened with the Godly items from PoE1? Have I missed anything? I think I was pretty thorough, because I left no stone unturned.