Ok, I'm pretty far into the game, and I'm quite blown away by it. It really comes down to the choice and consequence. Obsidian is simply a master at giving me multiple choices that all seem somewhat decent. This is a far cry from the Bioware model, which is basically be good/be a jerk. I enjoy Bioware's games because I get to be a save the world hero, but Obsidian is going much deeper with choice and consequence.
They did the same thing with Alpha Protocol. If you haven't listened to the Zero Punctuation Review of AP, he basically says Obsidian is showing off with the sheer amount of consequences to every one of your actions. They continue this on an even larger scale with FO:NV.
So basically I'm saying it is one of the greatest games I have ever played. Now I am not the type who cares about gameplay or glitches or inventory management or whatever. I care about story, character development, choice, and consequences. FO:NV possesses those in spades.
If you are on the fence because of concerns over bugs, get off it. Bugs are short term, they will get fixed, and the game is worth working around them a bit. Knock on wood, I've actually had zero issues with the game. It is brilliant.