I'm pretty sure it'd have to be Obsidian/Activision. And it'd be Vampire the Requiem, not Masquerade, these days.
But yes, give Brian Mitsoda free reigns on a WoD game and it could turn out amazing. Given how good his Bloodlines stuff was, I am now very excited to learn more about Project Georgia (where he is creative lead).
Requiem would be great. Having Mitsoda on board is one of the best things to happen.