Took me a couple of attempts, but i did it, despite not knowing what would do damage to her or not.
I generally tried to keep all characters as far from her as possible to avoid that insane AoE one shot attack, only having my tank being at her holding the aggro.
I spent most of my time healing, buffing up and casting spells and maelstroms on her, maelstrom seems to be doing quite a bit of damage, so that's definitely viable. Never really used paralyze, only took control of her once with my cipher to kill off the minions and position my charcters. I barely killed her. My tank died while she had very little hp left, so it was a race against time.