I was waylaid by a golden saint not once but twice recently in my travels. This may seem like a nuisance, but in fact it's great fortune as golden saints supply among the best souls in the game, and I just happen to always carry grand soul gems on me. I turned one of the golden saint souls and an adamantium mace into this:
That mace makes me nearly invincible in melee and 400 charges means that it will take a loooong battle for it to run dry. I guess the best defense against it would be paralyze, can't life-leach if I'm not attacking. I'm not sure yet what to use the other golden saint soul gem on. Anyway, I hope I run across some more golden saints.