What I do like about Vampyr is the atmosphere and visual style, voice acting and facial animations (much better than Larian's), and the MC being generally nice and unintentionally funny. About a half of the game is spent asking people random questions about their lives and occasionally about quests. The cast is reasonably interesting and diverse, and surprisingly willing to talk about their love lives and childhood traumas to a random guy at night. Technically, the information gained increases the amount of XP from the NPC should the player decide to eat them, but doing so (eating them) also damages the District's health and blocks the good ending. On the negative side, only killing the civilians, including serial killers and gang leaders, has undesirable consequences. Slaughtering legions upon legions of vampire hunters is fine. Also, it is not possible to partially drink a civilian and let them be on their merry way, while insta-killing a vampire hunter by biting is not possible either*. Additionally, only some information leads to quests. So, you can't report the above-mentioned serial killer to the police or fix a patient's arm or encourage some criminal to become a law-abiding accountant. Still, overall, it is an enormous improvement over the developer's previous game, Remember Me, where because of the MC’s unavoidable actions, an assassin blew up a hospital and the MC herself caused a flood in several parts of the city. I can't quite recall if the MC was an antihero or not. If compared to other developers, the combat and controls are significantly better than in The Witcher 3, and the MC does not get stuck in book stacks nor suffers from falling damage.
*The XP gains from a civilian range from 500 to 5000, while a vampire hunter, even if he was repeatedly stunned and bitten, yields 5. Which is weird logically - the hunters seem healthy enough, but it does make sense from the gameplay perspective, as eating the civilians is supposed to be tempting.
While it is not the best game ever made, if you like action-adventures with light RPG elements, it might be an enjoyable experience. It is also on sale at the moment (80% discount).
Edit. Forgot to mention, the only unique boss so far is the Vampire Boss #3. The rest started to appear throughout the city.