Well it's based on a manga, that James Cameron had been planning to adapt for ages until he turned 110% of his attention to Avatar. At which RR was selected to direct.
I've never actually read the manga myself. But this hybrid style that they are going for is really weird. Hybrid in two ways. One, a mix of CGI and real people. Two, the anime aesthetic on Alita is not applied to the other androids. I can't tell if it's a movie aimed at kids, trying to capture a wider crowd, or in someway trying to tap in part to a simmering western fetish that the west, unlike Japan, is too prudish to wear bluntly on the sleeve. The whole fem-android trope clearly has always played to the later. Plus weird fudging of the aesthetic to cater to two crowds isn't helping it's case. I don't think it will be debase, but It seems like the creators have some strange priorities while exploring transhuman ideals.
I like Waltz and Connelly a lot, so maybe something will come of this. Not holding my breath. The trailer seems to over sell itself.