I think the Shadowrun setting is rubbish, people only talk about it because they remember the nintendo game. But seriously, it's unbelievably stupid. It was just some hoodlums sitting around in their basement going "We like D&D and we like Cyberpunk... how about we put them together? Like mustard on a custard pie!"
I think they should make an horror platform game set in Jane Austen's books, that would be terrific idea. Just add zombies and you're ready to go.