Could happen only if its a plot point, systemically...nope. Ship is essential for navigation, even getting it seriously damaged/hindering its speed too much may not be an option. Also I expect the crew will be too hard to get killed in dangerous situations since they won't be generic NPCs.
I'm hoping for occasional sea creature sightings around the ship while cruising; whales, dolphins, sharks etc. Wonder how big is the visible ocean around the ship...
Aye, but the possibility of getting shipwrecked makes adventuring at sea much more dramatic. Otherwise you're just tourists. Besides, it's an opportunity to strip the party of their gear and have them start over.