This leaves me very excited, especially the bit about combat skills giving dialogue options. However, there are two or three things that would leave me very happy if they were changed:
The yellow font seems a bit too flashy for my tastes. It would be nice if they changed it to something a bit more subdued.
The display of +1 reputation on screen takes away from character development, and turns conversation into a silly meta game instead of, you know, a conversation with an actual person. At the very least, hide the info from the main screen, and preferably make it a completely hidden variable. I hated it in your previous games, and I will hate it here.
Limit the amount of guns you can carry at a time. Going around with two hand guns and two rifles seems a little over the top for something set in the real world.
I'd really love to see a video of a conversation, mostly to see what the faces and animations will look like in the finished product.