In DS2 I controlled everything with the mouse... I only used the 'M' key for chugging mana potions & 12345 for activating a power. I rarely chugged health potions, since it was inefficient compared to a healing mage autocasting a healing spell & spirit embrace. Oh, and I also used 'F' for focus fire occasionally.
For DS1, though, I used to have an entire page of hotkeys. Not that it was really necessary, though.