Some more ideas. 19th century Jules Verne-ish setting, a isometric real time roguelike, No health bar or inventory, just realistic portrait of your health and whatever you can carry around. So more or less game over if you break a leg or get some serious disease. Depends on the goal youd' have.
An rpg with any of these settings , all without magic:
-Nazi elves
-Cyberpunk elves, dwarves,... basically Shadowrun without magic and dragons...
-Orcs and elves,... in space.
xD