I have almost finished a Solo Chanter PotD run, so it is definitely possible! I actually recommend Mig 18, Con 10, Dex 4, Per 18, Int 10, Res 18. Here is why. You don't have a very large health pool in the first place, so you are getting only modest benefits from constitution. Might allows you to do considerably more damage with an early Fine Arbalest you can find, and guns later in the game. This early damage is actually EXTREMELY important for alpha striking enemies:
You can one shot Wicht, lesser spiders, skuld whelps, etc. You can put many other enemies into Near Death with that opening shot. You can actually use a leeching weapon more effectively to stay alive later in the game.
DEFINITELY take Blessed Was Wendrigh and Fast Runner. They do stack and become your bread and butter. It's entirely possible to kite a large number of enemies in this game, and you should abuse the **** out of this. Seriously, alpha strike for huge damage, kite until you summon, wreck face, and run away if things go south. It is completely viable to assassinate one enemy then run away, assassinate another enemy then run away, etc. Mechanics 9 eventually (so you get 11 from the +2 gloves), but this is not an immediately pressing need. Just get Mechanics 5 at your first level up and you should be good for a while, unless you want to cheese your way to a life leech sword which needs 10 mechanics ASAP.