Is there any accurate way to determine this point?
With regards to combat - my first playthrough was with a nosferatu and i mainly used melee weapons this is due to the fact that max potence really buffs your strength.
My second was with a toreador and i was finding the melee combat to be difficult so tried using ranged weapons more. With max auspex and ranged skill the shots were very powerful and accurate.
So basically the type of combat depends upon the clans and their respective disciplines.
Currently playing as a crazy gangrel, quite different to my first playthrough... its surprising who i can kill.