I just had that bit with the vampires in Fallout 3 and this wanker was trying to yap on about poetry and somesuch and IN MY HEAD I thought "This fool isn't going to let me complete my mission peacefully is he" So I hit the inventory, drank a bottle of beer, waited until they were assembled for a meeting, laced the entire area with landmines, and retreated to a safe distance. Then I had another beer. they got up, dispersed and mines started going off. They all died. I had another beer.
Maybe not funny to you guys, but I perfectly hit my funny bone.