I have a similar problem with the mouse clicks and figured I'd check the forum to see if I'm the only one. Looks like I'm not. To be clear, I can click on menus and objects, but it usually takes at least two or three of them to register, and that's very frustrating when in combat for example. I'm using windowed mode so I'll check the fullscreen to see if it persists. Thanks for being on top of things, gentlemen!
Edit: I turned off the overlay and the mouse clicks are registering as they should.