"Fire!..."
What an idea. Given that some indie group could very well make something this up, I don't see any obvious problems. Then again, why would it need to be a CP title? How about an rpg where you fight against pollution or pollute in general. Say, both sides would make it in order to survive, but they'd see each other as an abomination and there couldn't be a peaceful ending to their struggle(or could there?).
Reminds me a bit of Nausicaa, actually.