Oof, coming in sideways would definitely affect me.
The first game I remember really making me sick was Descent in 1995. Strangely, I used to be able to stomach the likes of Doom / Hexen / Heretic / RotT / Duke Nukem but now not so much. Even FO:NV hit me after an hour or so. The cause? Well, theres a lot of damage between my ears, so who knows?