There's certainly the possibility for a more personal storyline in DA2, for instance about a Grey Warden seeking to find a cure for the taint, it's hard to imagine BioWare would simply go for the next ancient evil/blight to rise from oblivion.
Even the Witcher had a hint of this, with that other guy Bellegar/Beregar looking for a cure for the mutation because he wanted a normal life. Grey Wardens are very similar to Witchers, anyhow, save that Witchers get a much longer lifespan instead of just 30 years.
Oh, and for laughs, the supposed werewolf companion should be named Cernd. Nobody ever used that poor guy.