The Renaissance was an era of great scientific & cultural upheaval in spite of the Church, that nearly ruined it with the Inquisition, the 80-years war & 30-years war. Basically there was nearly 200 years of non-stop war during the Renaissance caused by the Church's fanatism.
Before the Renaissance, the only big war was the Hundred years war, which was solely political. Yet the Church left a mark with the Crusades that exists until this day... without the Crusades, mayhap the Christian west & Muslim world would've been not so much apart as they are today.
Also do not forget how the Church destroyed a fledgling new religion in the Languedoc, by instigating the genocide of the Cathars. If this religion could've spread more through Europe before it was snuffed out, it might've changed the entire history.