I was about to despair and write off a handful of point and click adventures that I bought recently, as it seemed that no matter what, I just couldn't get them to run on Windows 7 64bit. Having resigned myself to uninstall and then reinstall them on my very old PC, I made a last ditch attempt with Google... alexborisov.org to the rescue
The trick was not just to run them in compatibility mode (I tried windows XP sp2 and sp3 compatibility, Windows 98 was no help either), but to run them in Windows NT4.0 Sp5 compatibility mode. Not kidding, they run as smooth as a politicians lies now. Time to revisit Still Life, Syberia, Post Mortem and a few others
Edit: Currently playing 'The Greate White Destroyer', where you get to play a shark. You have to eat Fish, Swimmers, Scuba Divers, sink boats etc. Cute little game.