As Morrissey said: America is not the world. These are the forums of an US-based publisher so I can understand that an US setting would appeal to the most people here. On the other side: if you got for isometric 2d graphics, survival elements, choice and consequence, complex combat mechanics, realistic encumbrance and wounds, you don't really care to appeal to the largest target audience anyway.
You're perilously close to being too hip for the room.
Because Americans have little to no interest in the rest of the world. Sad but true.