This is one of my top 5 favorite setting for a game. I've always wanted say a KotoR like experience but in say the Star Trek universe.
So here is my plan. Since OEI is now buddy buddy with Bethesda now, and since Bethesda has the right's to Star Trek Games (I don't fully understand the scope of the Star Trek rights Beth/Zenimax have, other than that one game they made via a different studio, I'll just *assume* they could approach Universal with the idea), all OEI needs to do is a Prototype and pitch this to Beth/Zenimax. And with Feargus' 150% Speech Skill, I think it could be done!
The setting could take place after 2269 (The end of Season 3 in ToS), and feature all new people. You could still have some references to the original Star Trek cast members and maybe a cameo or 2.
A Star Trek RPG would be PURE AWESOME!