I've tried getting into Yakuza, and while the atmosphere is great, I find that since i've grown up a PC gamer who never really uses a gamepad.. It's fairly awkward and not so much a fun gaming experience.
My moments of OCD mean I cannot stop myself attempting all the mini-games, which are basically terrible to try with a keyboard and mouse. And if you don't have the memory twitch of how the buttons are laid out on the gamepad, you're constantly having to look down to double check that you're hitting the right one, which kills you on all the mini-games.
Edit: To help clarify, I've been gaming with a mouse and keyboard for the last 30 years. Over that period of time, I think i've spent.. maaaybe 100 hours playing with a gamepad. Quite likely less.