Quite right: since this is a game, there's even less (reasonable) obligation than usual to have to "interact" with NPCs than usual, eh?
Look at you Barti, catching me out with logic
Fair enough, but what about missing out on side quests or content related to Romance? Do you really want to deny yourself extra gaming time just because of an aversion to Romance, if you think about it honestly Barti you will realize I'm right
Well in ME, there's none. The "romance" is just them banging you before the Final Mission and/or some maudlin stuff in the case of the Final Final Mission.