Sure, but you might prefer certain outcomes more than others. If you are really curious what will happen if..., you can make this scenario happen. If I were planning to do one playthrough only, I would regret suppressing Iselmyr, or not kidnapping orlan baby. As is, I will leave those for later playthoughs.
Well I know that sooner or later I will reply this game.. it might be 6 months it might be a year, but I most likley will, then it would give me the option to start over and try some weird premade outcome.