Not really. It takes the old chracters of Marvel and their origins in the modern day instead of having them start off in the 1960s. Such as today Peter Parker got a job at the Bugle not as a teenager photographer but as a web designer for their newsite. Also it retunes them just a bit such as with the Hulk. Gamma irradiated adrenaline and testosorone (msp) can make one very destructive and well, very horny.
They also did some revisioning such as Gwen Stacy being killed by Carnage, which wasn't Cletus Cassidy, but a failed clone, I think, of Parker made by Doctor Conner.