Alright, let's see. Some of the unique weapons I've used the most;
Lord Darryn's Voulge (Pollaxe, soulbound) - One of the few weapons in Deadfire to have an elemental damage type (Shock), like Bittercut in the first game. Has good synergy with Barbarian Carnage, and is a powerful stat stick for certain Druid builds.
Wahai Poraga (Pollaxe) - One of the first uniques you can get that targets multiple enemies with each attack, works well with one-man-army builds.
Rannig's Wrath (Rapier) - Probably the single most accurate melee weapon in Deadfire, having an additional Accuracy bonus on top of the innate Rapier bonus and the modal.
Min's Fortune (Sabre) - One of the first unique Sabres you can find, it's a Crit-focused type of weapon. Think of it as the successor to Resolution.
Duskfall (Sword) - Starts off good as is, and has enchantment options that make it very versatile.
Whispers of the Endless Paths (Greatsword) - Likely to be the very first Greatsword you can get. Lower base damage than all other Greatswords, but hits multiple enemies and comes with very good enchantment options.
Tarn's Respite (Sabre) - Has a Deflection-draining enchantment option, which is very useful.
Pukestabber (Dagger) - Figure out how to work around its quirks, and it's integral to achieving the fastest attack speed in the game.
Eager Blade (Estoc) - Pretty nice enchants, and probably the best AR-breaker you can get until late-game.
Stalker's Patience (Spear) - Ideal for tanks due to the +Engagement modal, and Wounding gives it high damage potential.
Modwyr (Sword, soulbound) - Not spectacular damage-wise, but it's one of the few ways to achieve Immunity from Intellect Afflictions (aka Confused, Charmed, Dominated).
Squid's Grasp (Rapier) - Not as outright accurate as Rannig's Wrath, but comes with some very good defensive options.
The Willbreaker (Morningstar) - An ideal option for Barbarian Brute Force builds.
Grave Calling (Sabre) - Useful against Vessels in particular.
Voidwheel (Greatsword) - One of the highest damage potential amongst 2H weapons, but watch out for the self-damage.
Engoliero do Espirs (Estoc) - Excellent against crowds thanks to the Ghost Blades proc.
Kapana Taga (Club) - Has the fairly rare Slash/Crush damage combo, comes with very good enchantments for One Versus Many situations.
Oathbreaker's End (Battle Axe) - Does brutal damage, especially against crowds if given the right enchantment.
Scordeo's Edge (Sabre) - Probably the single best 1H melee weapon in the game, if you opt for the enchantment option that gives the wielder a chance to straight up ignore Recovery for a set amount of time.
Edited by Ascaloth, 13 September 2018 - 01:58 AM.