So I was going to investigate the Silver Rush for Cass who was getting impatient with me delaying to acquire evidence; the guard asked me to leave behind all my weapons at the door, which I didn't exactly protest against since my character has 100 Speech, but then upon entering some guy thanked me for bringing Cass to him, a previously unknown quest updated (lolwut?) and suddenly everyone wanted to kill her and me.
Hence out-of-the-blue I was caught unarmed in a firefight with 8 goons or so. The only that was missing, was the door locking behind me, Alpha Protocol-style. I had to run outside, where my guns magically re-equipped and killed everyone upon re-entering (the goons mostly carried energy weapons, which thankfully suck balls in this game).