I am ver yflexible on certain issues but when it comes to games, no I am not. A CRPG is more than a sumof its parts, it is a synergy of the various components that goes into it. The rules system, the graphical style, the storyline, the voice acting, the setting, and the music needs to build upon one another to build a proper CRPG. If even one or more of these aspects are out of whack then the whole game is worthless.
Fallout is a culmination of these aspects to create a style in which its original programmers and designers created one of the best games ever made. Any drastic deviation from what was set in Fallout 1 and Fallout 2 wil only result in garbage. Given Bethesda's design philosophy only garbage can be the result of them making Fallout 3.