Nvidia GTX 680 latest drivers, it's pretty much bug-free and 100x better than the original Bioshock which was a crash-fest for me
Original Bioshock on PC was just a crappy Xbox-to-PC port. Like "it won't work at all if you have a certain brand of sound card" bad.
yeah as i recall i was using 8800 gtx sli and on windows vista, disabling one card would fix most of the crashing (but not the ones in the menus), and make it run half as fast, such a crappy dilemma back then