The funny thing about living someplace is that you tend to learn a lot about those areas you go. I haven't been down on the strip for a long time. Like a lot of locals, I don't go there unless it's necessary. For that reason, I'm not going to second guess any cool themes you might have in mind. For all I know, they've changed it. Second of all, Vegas is a high profile city with a conspicuous night life. It's the perfect place for a vampire because the city is often busier at night than in the day.
It's got a lot of glitz, but it's got some ugly areas of town also, and there are casinos everywhere. You can have more upscale areas like... umm... The District in Henderson and seedy areas like New Town. New Town is literally like you see in some films. Gun fights, murders, prostitution, etc. I've had the joy of visiting the place while on a ridiculous ride along. (My brother is a seargent in the Las Vegas Metro, and so I finally gave in and went on a ride along.) Anyhow, it gives variety.
Finally, the desert is simply beautiful. I hav to admit that it's probably not as beautiful to some poor bastard who's stuck indoors all day, but the mountains and the basin make for wonderful sun rises and sunsets.
Ender, I'm really looking forward to playing in a Vegas setting. I've lived all over the place, but Vegas has grown on me over the years. This is going to be soooo cool.
...And I managed to get another player for my local DnD group today. Woo Hoo!!! My PnP experience has taken a turn for the better recently.