I ****ing hope not. That's so annoying. Screw realism.
If there's no gameplay difference between a lethal and a non lethal takedown, the choice becomes essentially meaningless.
There was no difference in Deus Ex, and yet it wasn't meaingless because characters and dialogue develope differently based on your actions (hopefully AP extends on this, because while the dialogue changed, the consequences didn't change much - which was still fine - a lot of us are roleplayers, Pidesco).
Actually even in gameplay non-lethal was meaningful because it was usually the quickest, most silent way to remove an enemy, which certainly alters gameplay.
SO YOU'RE WRONG!!!!111