Godwin's Law prevails again.
Of interest: In the article, did it mention the proposed multiple endings as being connected to the karma system? If so, "multiple endings" is misleading. Multiple endings would imply different paths to the end of the game, whereas outcomes dependent upon accumulated karma would imply something lesser. To put it in simpler terms, it very well could be that there are 9-12 different ending voiceovers, which are not determined by the actions you take at the end of the game but by your karma.
As well, it would seem to imply that instead of area-by-area epilogues ala the other Fallouts, Fallout 3 will have broad state-of-the-union style endings, which if anything would speak to a lack of attention payed to long-term consequences of actions.