As you say, the ending is crucial and there are a lot of loose plots to tie in and up. I think it will require an excellent (team of) writer(s) to accomplish with satisfaction, but then that is totally independant of the game mechanics.
So all the potential customers can hope for is a good writing effort on top of whatever game and platform released. But that's like saying I want to drive a car that has passed the mandatory safety tests -- it's self evident and therefore redundant.
A new team is just as likely to write a brilliant sequel as either OE or Bio.
Now if we could just get the game to work ...
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