Here's my wishlist, I know the first two points kind of go against what you guys have already stated:
Make it fully 2d and be proud of it. Look at Rayman Origins and King of Fighters XIII for example, just beautiful.
Co-op multiplayer with turn-based combat like Fallout. (action points, ho!) Pausing to make decisions takes you out of the action and you generally have to pause a lot anyway, plus it doesn't work in multiplayer.
Just get rid of the laundry list-style questlog and replace it with a journal that holds essential information. It'll send a message that players have the freedom and